Cerebral Arteriolar Damage by Arachidonic Acid and Prostaglandin G 2
- 12 September 1980
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 209 (4462) , 1242-1245
- https://doi.org/10.1126/science.7403881
Abstract
Application of arachidonic acid or prostaglandin G 2 to the brain surface of anesthetized cats induced cerebral arteriolar damage. Scavengers of free oxygen radicals inhibited this damage. Prostaglandin H 2 , prostaglandin E 2 , and 11,14,17-eicosatrienoic acid did not produce arteriolar damage. It appears that increased prostaglandin synthesis produces cerebral vascular damage by generating free oxygen radicals.Keywords
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