INDUCTION OF TRANSPLANTATION TOLERANCE IN GUINEA PIGS BY SPLEEN ALLOGRAFTS
- 1 January 1982
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 33 (1) , 45-51
- https://doi.org/10.1097/00007890-198201000-00010
Abstract
Four hundred and ten heterotopic spleen transplants were performed in inbred guinea pigs of strains 2 and 13 whose major histocompatibility complex differs only in the I region and which rapidly reject reciprocal skin allografts. Spleen allografts from strain 13 to strain 2 survived throughout the lifetime of the hosts, whereas spleen allografts from strain 2 to strain 13 were rejected within 3 weeks. Animals not rejecting their spleen transplants were specifically tolerant of donor strain skin allografts. Strain 2 recipients of strain 13 spleen grafts had a surprisingly high mortality from graft-versue host disease which peaked at 6 weeks after transplantation.This publication has 6 references indexed in Scilit:
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