Relationship of nonspecific antiarrhythmic and negative inotropic activity with physicochemical parameters of propranolol analogs

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Abstract
To separate the nonspecific antiarrhythmic activity of propranolol from its negative inotropic effects, analogs containing hydrophilic and lipophilic substituents on the N group and on the naphthyl ring were prepared and tested in an isolated [rabbit atrial] tissue preparation. Since the analogs contain a very hydrophilic N group, a high antiarrhythmic/negative inotropic effect ratio was expected. Both effects increased simultaneously while the lipophilicity of either the N group or ring substituent was increased.

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