Association of the renin gene polymorphism with essential hypertension in a Chinese population
- 28 June 1997
- journal article
- Published by Wiley in Clinical Genetics
- Vol. 51 (6) , 370-374
- https://doi.org/10.1111/j.1399-0004.1997.tb02493.x
Abstract
To study the association of renin gene polymorphism with essential hypertension in the Chinese population, 86 hypertensive and 107 normotensive subjects were enrolled from an epidemiologic survey. Leukocyte DNA was extracted and digested with Hind HI and Bgl I restriction enzymes. Southern hybridization was done with digoxigenin‐incorporated renin gene probes generated by polymerase chain reaction. The restriction fragments were detected by anti‐digoxigenin antibody and enzyme methods. Two Hind III polymorphysms of the renin gene (8.7kb and 6.2kb) were identified. The allele frequences were 129(75%) and 43(25%), respectively, in hypertensives; they were 139(65%) and 75(35%), respectively, in normotensives (χ2= 4.074, p = 0.044). The genotypes of 8.7/8.7,8.7/6.2 and 6.2/6.2 were significantly different between hypertensives and normotensives, being 45(52%), 39(45%), 2(3%) and 48(45%), 43(40%), and 16(15%), respectively (χ2= 9.002, p = 0.011). The Bgl I polymorphism did not show a difference between hypertensives and normotensives. Thus, we conclude that the renin gene Hind III polymorphysm is associated with hypertension in this Chinese population.Keywords
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