Effects of Flushings with an Acidic Calcium Phosphate Solution on Fluoride Binding and Caries in Rat Teeth

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Abstract
This investigation, comprising three studies, measured the effects of flushing with an acidic calcium phosphate solution (CPS) on the cariostatic benefits of fluoride. In the first two studies, the rats received fluoride in the drinking water (2.5 ppm F) after initiation of the caries challenge. In contrast, in the third study, the animals received treatments as oral flushing before initiation of the cariogenic challenge. In all three studies, rats that received CPS in conjunction with fluoride exhibited a numerically lower mean caries score than those that received H2O in conjunction with fluoride. Moreover, in the third study, the group receiving oral flushing of CPS followed by NaF (10,000 ppm F) for 3 successive days exhibited a significantly lower incidence of dental caries and higher concentration of enamel-bound fluoride than did the group treated with a H2O-NaF sequence. A significant negative association (––0.65) between fluoride and caries was noted when the dentition of all rats in the third study were considered.