Experiments on the chemotherapy of cancer

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Abstract
The glycolysis and respiration of several strains of grafted tumours with growth rates varying from 0.01 to 1.35 mm. per day are not proportional to the rate of growth and vary within a narrow range. The values for glycolysis and respiration of tissue from grafted tumours, the growth of which was inhibited by administration of 1:2:5:6-dibenzanthracene, 1:2:5:6-dibenzfluorene. sodium-sulphanilylsulphanilate, [alpha]-nitroso-[beta]-naphthol and 4:4''-di-amino-2:2''dinitrodiphenylmethane, were not significantly lower than values of untreated tumours. The inhibition of growth produced by trypan blue was accompanied by decrease in respiration and glycolysis while that produced by pp''-diaminodiphenylsulphoxide was accompanied by reduction in glycolysis only. Inj. of isamine blue did not, inhibit tumour growth nor reduce the metabolism.