The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506

Open Access

15 September 1998

journal article
research article
Published by Wiley in European Journal of Biochemistry

Vol. 256 (3) , 528-534
https://doi.org/10.1046/j.1432-1327.1998.2560528.x

Abstract

Biosynthesis of the macrolactone ring of FK506 involves 10 elongation cycles that mechanistically resemble the steps in fatty acid synthesis. Sequencing of a 40‐kb DNA segment of the FK506 gene clust...

Keywords

MODULAR POLYKETIDE SYNTHASE
FK506 GENE CLUSTER
RAPAMYCIN.