In vitro Sensitivity of Some Bacteria, their L Forms and Pleuropneumonia-Like Organisms to Antibiotics.

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Abstract
The sensitivity of PPLO strains of various origin and of several bacteria and their L forms was examined in the presence of nine antibiotics. All PPLO strains and L forms were highly resistant to penicillin. The sensitivity of L forms to the other antibiotics was comparable to that of the parent bacterium. However, the L forms of streptococci and of one Vibrio strain were consistently less sensitive to bacitracin than their bacterial forms. The sensitivities of the parasitic PPLO strains to the various antibiotics were uniform; they were markedly resistant to bacitracin and erythromycin, like some bacteria. Three saprophytic PPLO strains were noticeably less resistant than the parasitic strains to several antibiotics, especially to erythromycin. The sensitivities of all strains of PPLO, of bacteria and of L forms of these bacteria were on the whole comparable. The behavior of PPLO in the presence of antibiotics contributes to the concept that they are closely related to bacteria.