COMPARISON BETWEEN THE EFFECTS OF INTRAVENOUS AND INTRAPORTAL VASOPRESSIN IN NORMAL RATS, MALNOURISHED RATS, AND RATS TREATED WITH CARBON TETRACHLORIDE

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Abstract
SUMMARY: In normal rats intravenous vasopressin produces a greater effect on blood pressure than the same dose given intraportally. Following treatment with carbon tetrachloride the response following an intraportal injection approximated to that following an intravenous injection. Supplementation of the diet with methionine, vitamin B12, or choline chloride did not restore to normal the responses to vasopressin of rats injected with carbon tetrachloride. In malnourished rats an intraportal injection of vasopressin raised the blood pressure almost to the same levels as that obtained by giving the same dose intravenously.

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