Perspectives on cognitive domains, H3receptor ligands and neurological disease
- 1 October 2004
- journal article
- review article
- Published by Taylor & Francis in Expert Opinion on Investigational Drugs
- Vol. 13 (10) , 1237-1248
- https://doi.org/10.1517/13543784.13.10.1237
Abstract
Histamine H3 receptor agonists and antagonists have been evaluated in numerous in vitro and in vivo animal models to better understand how H3 receptors modulate neurotransmitter function in the central nervous system. Likewise, behavioural models have explored the hypothesis that changes in neurotransmitter release could enhance cognitive function in human diseases. This review examines the reported effects of H3 receptor ligands and how they influence cognitive behaviour. These data are interpreted on the basis of different cognitive domains that are relevant to neuropsychiatric diseases. Because of the diversity of H3 receptors, their function and their influence on neurotransmitter systems, considerable promise exists for H3 ligands to treat diseases in which aspects of learning and memory are impaired. However, because of the complexities of the histaminergic system and H3 receptors and the lack of clinical data so far, proof of principle for use in human disease remains to be established.Keywords
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