Mechanisms for HIV Tat upregulation of IL‐10 and other cytokine expression: Kinase signaling and PKR‐mediated immune response
- 5 May 2005
- journal article
- Published by Wiley in FEBS Letters
- Vol. 579 (14) , 3055-3062
- https://doi.org/10.1016/j.febslet.2005.04.060
Abstract
HIV Tat has been known to have multiple regulatory roles including replication of HIV and modulation of cellular kinases. We investigated whether signaling kinase PKR plays a critical role in mediating Tat-induced cytokine dysregulation. We showed Tat induction of IL-10 dysregulation is associated with PKR activation. To examine the mechanism involved, inhibition of PKR activity abrogated the Tat-induced cytokine induction. We next identified that the MAP kinases including ERK-1/2 and p38 are downstream of PKR in these Tat-induced pathways. Thus, PKR may play a critical role in mediating the subversive effects of HIV Tat resulting in IL-10 inductionKeywords
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