HYDROCORTISONE SUPPRESSION OF STRESS-INDUCED ADRENAL 17-HYDROXYCORTICOSTEROID SECRETION IN DOGS1

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Abstract
THE administration of adrenocortical hormones to intact rats has been shown to inhibit pituitary secretion of ACTH (1–4). Sydnor has recently reported that the increase in blood ACTH which occurs in adrenalectomized rats subjected to ether anesthesia is suppressed by the administration of large doses of hydrocortisone (5). In these previous investigations, ACTH activity was determined by alterations in either the weight or ascorbic acid concentration of adrenal glands of rats. Exposure to 20% CO2 (6) and the surgical trauma of adrenal vein cannulation (7) are two stimuli independently capable of producing increased pituitary-adrenal activity in pentobarbital-anesthetized dogs. In the present investigation the effect of these two stimuli upon the adrenocortical response in dogs with increased plasma concentrations of 17-hydroxycorticosteroids was studied. Adrenocortical function was determined by measuring 17-hydroxycorticosteroids in adrenal venous blood. This technique provides a direct and specific index of the secretory activity of the adrenal cortex.

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