LEISHMANIA MAJOR SOLUBLE EXO-ANTIGENS (LmSEAgs) PROTECT NEONATAL BALB/C MICE FROM A SUBSEQUENT CHALLENGE WITH L. MAJOR AND STIMULATE CYTOKINE PRODUCTION BY LEISHMANIA-NAÏVE HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS

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Abstract
The vaccine potential and immunogenicity of soluble Leishmania major exo-antigens (LmSEAgs), a potentially novel source for vaccine candidates for leishmaniasis, were evaluated in neonatal BALB/c mice and with human peripheral blood mononuclear cells. Vaccinated neonatal BALB/c mice resisted infection with L. major, and lymphoid cells from the mice proliferated when restimulation with LmSEAgs and produced interferon-gamma and some interleukin-4. In addition, LmSEAgs stimulated human peripheral blood mononuclear cells to produce large amounts of interferon-gamma and some interleukin-5. This finding suggests that LmSEAgs may be a vaccine candidate for leishmaniasis in humans.