Disappearance of125l-Labelled Rat Growth Hormone in Nephrectomized and Sham Operated Rats
- 1 January 1975
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 7 (02) , 135-138
- https://doi.org/10.1055/s-0028-1093764
Abstract
125I-labelled rat growth hormone (GH) was injected I.V. into rats immediately after nephrectomy or a sham operation. Serial blood samples were then taken for 2 hr from an indwelling arterial cannula. The rates of removal of trichloracetic acid precipitable radioactivity and immunoreactive 125I-GH were both significantly decreased in the nephrectomized rats. Polyacrylamide gel eletrophoresis of plasma samples taken at 5 min and 120 min confirmed the observation that GH was removed from the circulation more slowly in the anephric rat. It is concluded that in the rat the kidney contributes significantly to the clearance of GH from the blood.Keywords
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