Binding and catalysis with flexible locks and flexible keys1
- 1 October 1995
- journal article
- research article
- Published by Taylor & Francis in Supramolecular Chemistry
- Vol. 6 (1-2) , 41-47
- https://doi.org/10.1080/10610279508032518
Abstract
In the final structure of an enzyme-substrate complex, or of a related molecular complex, the two components may fit together in a lock and key relationship, but flexibility is often needed in the binding process. Furthermore, flexibility is needed in enzyme-substrate complexes and their mimics to accommodate the geometric changes that the reaction causes. Examples of such situations from enzyme mimic studies are described.Keywords
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