Polysaccharides in fungi. XIII. Antitumor activity of various polysaccharides isolated from Dictyophora indusiata, Ganoderma japonicum, Cordyceps cicadae, Auricularia auricula-judae, and Auricularia species.

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Abstract
A mannan and water-soluble glucans from D. indusiata, a water-insoluble glucan from G. japonicum, a galactomannan from C. cicadae and acidic heteroglycans from A. auriculua-judae and Auricularia spp., whose structural features were previously reported, were tested for antitumor activity against s.c. implanted sarcoma 180 in mice by i.p. administration. Considerable antitumor activity was observed .times. with partially O-acetylated (1 .fwdarw. 3)-.alpha.-D-mannan (T-2-HN) at doses of 10 mg .cntdot. kg-1 .cntdot. d-1 .times. 10, water-soluble (1 .fwdarw. 3)-.beta.-D-glucans having .beta.-1 .fwdarw. 6 linked D-glucosyl side chains (T-4-N and T-5-N) at doses 5 or 10 mg .cntdot. kg-1 .cntdot. d-1 .times. 10 and a glucuronoxyloglucomannan (U-3-A) at doses of 25 mg .cntdot. kg-1 .cntdot. d-1 .times. 10.