Leucine-Induced Hypoglycemia

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Abstract
In 1956 Cochrane et al.1 first reported that the hypoglycemia of some infants with "idiopathic familial hypoglycemia" was sharply accentuated by the oral administration of L-leucine. Their observation has been confirmed many times,2,3 although most investigators have found that only one quarter to one third of children with "idiopathic hypoglycemia" are leucine sensitive. ("Idiopathic hypoglycemia" most probably represents a heterogeneous group of etiologic entities but excludes hypoglycemia due to known deficiencies of pituitary or adrenal function, islet-cell tumor, hepatic disease, hypoglycemia due to known specific hepatic enzyme defects and transient hypoglycemia of the newborn infant.) When Schwartz and his associates . . .