BLADDER CANCER IN YOUNG WOMEN

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Abstract
The authors describe a population-based case-control study of cancer of the urinary bladder in New York State women aged 20–49 years (173 matched pairs) in 1975–1980. Both known and suspected risk factors for bladder cancer were examined for these rare, early-onset female cases. The odds ratio (OR) for cigarette smoking was 2.4 (95% confidence interval (Cl) = 1.5–4.0). Cases consumed more coffee per day than did controls (p <0.05). More cases than controls reported heavy use of drugs that contained phenacetin (OR = 6.5, 95% Cl = 1.5–59.2). In addition, more cases than controls reported that they had had a thyroid uptake procedure with radioactive iodine (iodine-131) (OR = 3.7, 95% Cl = 1.4–11.0). The odds ratios for these factors remained elevated after simultaneous adjustment with conditional logistic regression models. Consumption of artificial sweeteners, occupational history, bladder or kidney cancer in a first-degree relative, and a history of bladder infections were examined and found not to be risk factors for bladder cancer in this study.

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