Enzyme Induction
- 18 March 1976
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 294 (12) , 646-651
- https://doi.org/10.1056/nejm197603182941206
Abstract
Models of Enzyme InductionThe results presented in the preceding sections of this review did not appear to be compatible with a model of enzyme induction in which the inducer acts exclusively at the gene level to stimulate specific mRNA synthesis (as described below). Therefore, Tomkins and his colleagues presented a model in which the inducing steroids were thought to have a single action: to antagonize a labile post-transcriptional repressor, which both inhibits messenger translation and enhances messenger degradation.64,75,86 Since most models of the mechanism of enzyme induction in higher organisms have been based on models derived from the study . . .This publication has 39 references indexed in Scilit:
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