The Interference of Human IGG with the Double-Antibody Radioimmunoassay of Thyrotrophic Hormone and its Clinical Significance

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Abstract
1. High values for plasma thyrotrophic hormone, which did not correlate with other parameters of thyroid function, were found in patients with abnormally high plasma immunoglobulin concentrations. 2. Results indicate that human IgG interferes with the post-precipitation double-antibody radioimmunoassay of thyrotrophic hormone. It is possible that this interference occurs with similar radioimmunoassays of other substances.