On the Origin of Human Basophilic Granulocytes

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Abstract
By a combined application of toluidine blue stain and naphthol AS-D chloroacetate esterase reaction on normal bone marrow smears metachromic and promyelocytic granules were demonstrated on the same cell. Precursors of basophils contain NASDCl-esterase activity, the intensity of which depended on the maturity of the cells. All transitional cells were found between non metachromatic promyelocytes with strong NASDCl-esterase activity and completely enzymatically negative metachromatic segmented basophils. It is concluded that basophilic granulocytes like monocytes, neutrophils, and eosinophils derive from non specific promyelocytes. Evidence has been presented for the transition of promyelocytic granules to specific basophilic granules. Our results confirm the dualistic view of the cytogenesis of leukocytes

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