Prolonged deterioration of ischemic brain energy metabolism and acidosis associated with hyperglycemia: Human cerebral infarction studied by serial 31P NMR spectroscopy
- 1 April 1988
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 23 (4) , 416-418
- https://doi.org/10.1002/ana.410230423
Abstract
We report on a patient with a large ischemic hemispherical stroke studied serially by 31P nuclear magnetic resonance spectroscopy. Persistent hyperglycemia was associated with prolonged acidosis in ischemic brain and failure of high‐energy phosphate metabolism to recover. These in vivo human data support the concept that hyperglycemia adversely affects ischemic brain metabolism, pH, and clinical outcome.This publication has 13 references indexed in Scilit:
- Intracellular acidosis during and after cerebral ischemia: in vivo nuclear magnetic resonance study of hyperglycemia in cats.Stroke, 1987
- Graded neurologic scale for use in acute hemispheric stroke treatment protocols.Stroke, 1987
- Hyperglycemia reduces the extent of cerebral infarction in rats.Stroke, 1987
- The association of hyperglycemia with cerebral edema in stroke.Stroke, 1986
- Effect of Glucose on Recovery of Energy Metabolism following Hypoxia—Oligemia in Mouse Brain: Dose-Dependence and Carbohydrate SpecificityJournal of Cerebral Blood Flow & Metabolism, 1983
- Increased damage after ischemic stroke in patients with hyperglycemia with or without established diabetes mellitusThe American Journal of Medicine, 1983
- Moderate hyperglycemia augments ischemic brain damageNeurology, 1982
- Factors limiting regeneration of ATP following temporary ischemia in cat brain.Stroke, 1982
- Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia in the cat. II. Regional metabolite levels.Stroke, 1980
- Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia in the cat. I. Local cerebral blood flow and glucose utilization.Stroke, 1980