Studies Towards the Total Synthesis of the Marine-Derived Immunosuppressant Discodermolide: Stereoselective Synthesis of a C9-C24 Subunit
- 1 June 1995
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1995 (SI) , 498-500
- https://doi.org/10.1055/s-1995-5276
Abstract
Enone 3, an advanced C9-C24 subunit of discodermolide, was synthesised in 17 steps starting from the ethyl ketone (R)-4. The sequence 19 → 23 was developed to introduce the Z-alkene at C13, enabling the conversion of 3 into the complete segment 5.Keywords
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