Enzymic Changes of Plasma Membranes Isolated from Mouse Liver During Experimental Viral Hepatitis

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Abstract
A study of some enzymatic activities on suspension of plasma membranes isolated from mouse livers in various phases of hepatitis induced by MHV-3 has been carried out. The alkaline ribonucléase did not show any significant change in hepatitic mice as compared with the uninfected controls. The p-nitrophenyl phosphatase and the two ATPases, Mg++- and Na+-activated, appear to be significantly reduced only at 36 h post virus infection. A different behaviour has been observed for the 5'-nucleotidase activity, which exhibits a highly significant decrease very early in the disease. This decrease is 32% at 12 h and 61% at 24 and 36 h after infection. The results are discussed in connection with the cytonecrotic evolution of the hepatitic lesion.

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