Increased [lactate] in working dog muscle reduces tension development independent of pH

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Abstract
Maximal intensity (isometric contractions at 2 Hz) and compared with control (C) conditions without lactate infusion. Each muscle was stimulated to work for two 60-min periods (separated by 45 min rest), consisting of three 20-min lime periods with either the high arterial lactate condition (high [La]) or C condition sequentially ordered within each 60-min work period. Blood flow and O2 delivery were held constant between the C and high [La] conditions. Arterial and venous blood measurements and muscle biopsies were taken (7 biopsies from each condition) during each condition. Lactate infusion significantly increased arterial [La] (C = 4.2 ± 0.2 mM vs high [La] = 14.4 ± 0.2; x̄ ± SE) and muscle [La] (C = 8.1 ± 0.8 mM w.w. vs high [La] = 12.0 ± 1.4) while arterial and muscle pH were unchanged between conditions. Muscle tension development was significantly reduced (C = 94 ± 2 N·100 g−1 vs high [La] =80 ± 3) during lactate infusion and muscle O2 uptake changed proportionally with tension. These findings support an effect of the lactate anion on tension development which is independent of pH. ©1995The American College of Sports Medicine...

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