Metabolic fate of furazolidone in rats.
- 1 January 1982
- journal article
- letter
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 30 (9) , 3435-3438
- https://doi.org/10.1248/cpb.30.3435
Abstract
The metabolic fate of the widely used veterinary drug, furazolidone (N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone) was examined in rats. When 14C-furazolidone was administered orally to rats, most of the radioactivity was recovered from urine and feces during the 1st 24 h, indicating rapid clearance of the nitrofuran from the animal bodies. The radioactivity in feces appears to be partly due to its biliary excretion and partly due to its exsorption. Two metabolites of the nitrofuran were isolated from the urine and unequivocally identified as 3-(4-cyano-2-oxobutylideneamino)-2-oxazolidone and N-(5-acetamido-2-furfurylidene)-3-amino-2-oxazolidone by comparison with authentic specimens.This publication has 4 references indexed in Scilit:
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