Two types of immature erythrocytic series in the human fetal liver.

Publisher Website
Google Scholar
Abstract
Cells of erythrocytic series in the human liver obtained from 109 embryos 28-49 days after ovulation and 76 fetuses between 8-22 wk of gestation were investigated by light and EM. Antisera against fetal hemoglobin (Hb-F) were used in the immunoperoxidase method to identify erythroblasts in the embryonic and fetal liver. Immunoperoxidase staining for Hb-F revealed that most of the hemopoietic cells found in fetal hepatic parenchyma were erythrocytic in nature. Cells of the erythrocyte series consisted of large immature cells which were usually invaginating into the cytoplasm of hepatocytes, and small mature erythroblasts which tended to gather in the subendothelial spaces of the sinusoids. The early hepatic erythroid progenitor cells observed in the intercellular spaces of the hepatocytes until 10 weeks of gestation (the early stage of hepatic hemopoiesis) distinctly differed in ultrastructure from the late hepatic erythroid progenitor cells which appeared after 10 wk of gestation (the late stage of hepatic hemopoiesis). Progenitor cells of the eythrocytic series and the hemopoietic stem cells in the early stage of hepatic hemopoiesis are morphologically differnet from those in the late stage. The cells of erythrocytic series in the liver in the early stage differ in the course of maturation from those in the late stage.

This publication has 0 references indexed in Scilit: