The ‘cation‐dependent’ mannose 6‐phosphate receptor binds ligands in the absence of divalent cations
- 12 September 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 237 (1-2) , 81-84
- https://doi.org/10.1016/0014-5793(88)80176-5
Abstract
The requirement of divalent cations for binding of the 46 kDa mannose 6-phosphate receptors to phosphomannan and pentamannose 6-phosphate-substituted bovine serum albumin was examined. Receptors from human liver and human brain bound to both affinity ligands in the absence or presence of divalent cations with similar efficiency. The requirement for divalent cations therefore appears not to be necessary for the binding.Keywords
This publication has 16 references indexed in Scilit:
- Intracellular movement of two mannose 6-phosphate receptors: return to the Golgi apparatus.The Journal of cell biology, 1988
- Insulin-like growth factor II receptor as a multifunctional binding proteinNature, 1987
- Is movement of mannose 6-phosphate-specific receptor triggered by binding of lysosomal enzymes?The Journal of cell biology, 1987
- 46-kDa Mannose 6-phosphate-Specific Receptor: Purification, Subunit Composition, Chemical ModificationBiological Chemistry Hoppe-Seyler, 1987
- [41] Low molecular weight phosphomannosyl receptor from bovine testesPublished by Elsevier ,1987
- Lysosomal enzyme binding to mouse P388D1 macrophage membranes lacking the 215-kDa mannose 6-phosphate receptor: evidence for the existence of a second mannose 6-phosphate receptor.Proceedings of the National Academy of Sciences, 1985
- Molecular forms of β-hexosaminidase and cathepsin D in serum and urine of healthy subjects and patients with elevated activity of lysosomal enzymesBiochemical Journal, 1983
- Localization of the sites of iodination of human .beta.2-microglobulin; quaternary structure implications for histocompatibility antigensBiochemistry, 1983
- Characterization of a membrane-associated receptor from bovine liver that binds phosphomannosyl residues of bovine testicular beta-galactosidase.Proceedings of the National Academy of Sciences, 1981
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970