Cytotoxic-induced fulminant hyperpyrexia
- 1 May 1980
- Vol. 45 (9) , 2249-2251
- https://doi.org/10.1002/1097-0142(19800501)45:9<2249::aid-cncr2820450905>3.0.co;2-6
Abstract
Two cases of fulminant hyperpyrexia induced by cytotoxic agents (bleomycin in a patient with lymphoma, and daunorubicin in a patient with acute myeloblastic leukemia) are presented. Each patient had a fever greater than 42°C, with a shock-like reaction and coma. Evidence of disseminated intravascular coagulopathy developed in the patient with bleomycin-induced hyperpyrexia and she died 24 hours afterwards. The pathogenesis and management of hyperpyrexial reactions to cytotoxic drugs are discussed.Keywords
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