Indolopyridoquinazoline Alkaloids with Antiplatelet Aggregation Activity fromZanthoxylum integrifoliolum
- 1 April 1996
- journal article
- letter
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 62 (02) , 175-176
- https://doi.org/10.1055/s-2006-957846
Abstract
Bioassay-guided fractionation led to the isolation of three indolopyridoquinazoline alkaloids, 1-hydroxyrutaecarpine, rutaecarpine, and 1-methoxyrutaecarpine as the active principles of antiplatelet aggregation in vitro, from the chloroform-soluble part of the fruit of Zanthoxylum integrifoliolum (Rutaceae). 1-Hydroxyrutaecarpine exhibited antiplatelet activity induced by AA and showed an IC50 value of ca. 1-2 µg/ml.Keywords
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