UREDOFOS - ANTHELMINTIC ACTIVITY AGAINST NEMATODES AND CESTODES IN DOGS WITH NATURALLY OCCURRING INFECTIONS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 37  (12) , 1479-1482
Abstract
A new broad-spectrum anthelmintic, uredofos, was tested in 146 dogs by single and multiple oral dosing. Single doses of 100 and 50 (but not 25) mg/kg were totally effective in removing Dipylidium caninum and Taenia spp. from 46 dogs with infections of tapeworms. Among groups of 15-20 dogs, the average percentage efficacies against Toxocara canis for single doses of 100, 50 and 25 mg/kg were 98, 96 and 81%, respectively. The average percentage of efficacies against hookworm (Ancylostoma caninum) were greater than 96% in dogs treated with single doses of 100, 50 or 25 mg/kg and were 100% in the 35 dogs given 2 or 3 treatments (24-h intervals) at dose levels of either 25 or 50 mg/kg. The whipworm, Trichuris vulpis, was not efficaciously eliminated by single doses of 25, 50 and 100 mg/kg (average percentage of efficacies of 30, 35 and 71%, respectively). Efficacy against T. vulpis markedly improved when 2 doses were given at a 24-h interval (average percentage of efficacies were 89% at dose level of 25 mg/kg and 99% at dose level of 50 mg/kg). At either dose (25 or 50 mg/kg), 3 daily treatments were no more efficacious against whipworms than were 2 doses. There was no evidence of drug toxicosis in any dogs tested. Uredofos is highly effective against canine tapeworms, ascarids and hookworms when given as a single dose of 50 mg/kg and against whipworm when given at a dose level of 50 mg/kg per day for 2 days.

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