Studies on Bayer 205 (Germanin) and Antrypol

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Abstract
Further observations were made on the method of determination of Bayer 205 (or Antrypol) previously described [Dangerfield et al. 1938]. The technique was simplified by the prepn. of colored discs for a Lovibond comparator. Plasma and serum obtained from blood containing Bayer 205 contain the same amt. of the drug. A modification of the method was devised for the determination of small amts. of Bayer 205 in urine. The difference between the values for the urine and an ultra-filtrate obtained by nitration through a standard collodion membrane is a measure of the Bayer 205 present. This difference gives a minimum value which can be rendered more accurate by the use of a correction value. This factor is usually between 1.1 and 125, and it can be detd. easily. Investigations have been carried out which support the suggestion made in a previous paper that a course of injections of the drug results in a more satisfactory maintenance of a significant amt. of Bayer 205 (or Antrypol) in the plasma over a long period than does a single injection of the same total amount. Some possible reasons for the long retention of the drug in the plasma are discussed.

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