Anti-Anaphylactic and Bronchodilating Action of a Beta-Adrenoceptor Stimulator, KWD 2131, in Human Lung Tissue

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Abstract
The .beta.-adrenoceptor stimulating agent KWD 2131 was studied with regard to inhibitory effect on allergen-induced histamine release from passively sensitized human lung tissue and relaxing effect on contracted small (diameter = 1 mm) and large (diameter > 3 mm) isolated human bronchi. The dose for 50% inhibition of the allergen-induced histamine release was 2 .times. 10-11 M. The potency of KWD 2131 was approximately 0.15 times that of terbulatine and 0.05 times that of isoprenaline in this respect. The bronchodilating potency of KWD 2131 was 0.02-0.03 times that of terbutaline. KWD 2131 is apparently a compound with preferably anti-anaphylactic potency in the human lung.