Differential expression of the mouse D2 dopamine receptor isoforms
- 28 January 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 278 (2) , 239-243
- https://doi.org/10.1016/0014-5793(91)80125-m
Abstract
We have identified and characterized the cDNAs corresponding to the mouse D2 dopamine receptors. We show that in the mouse the D2 dopamine receptor is found in two forms, generated by alternative splicing of the same gene, mRNA distribution analysis of areas expressing the D2 receptors shows that the larger form is the most abundant, except in the brain stem where the shorter form is predominant. Membranes of mammalian cells translently transfected with both forms of D2 receptor bind [1H]spiperone with a high affinityKeywords
This publication has 26 references indexed in Scilit:
- A second molecular form of D2 dopamine receptor in rat and bovine caudate nucleusNature, 1990
- Multiple D2 dopamine receptors produced by alternative RNA splicingNature, 1989
- Alternative splicing directs the expression of two D2 dopamine receptor isoformsNature, 1989
- The Major Dopamine D2 Receptor: Molecular Analysis of the Human D2ASubtypeDNA, 1989
- The guanine nucleotide regulatory protein-coupled receptors for nucleosides, nucleotides, amino acids and amine neurotransmittersCurrent Opinion in Cell Biology, 1989
- Mechanisms of signal transduction at the dopamine D2 receptorTrends in Pharmacological Sciences, 1989
- Cloning and expression of a rat D2 dopamine receptor cDNANature, 1988
- A family of receptors coupled to guanine nucleotide regulatory proteinsBiochemistry, 1987
- Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNAEuropean Journal of Biochemistry, 1980
- Multiple receptors for dopamineNature, 1979