Increased frequencies of chromosomal abnormalities in families with a history of fetal wastage

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Abstract
In 20 couples with a history of repeated fetal wastage, chromosomal abnormalities in cultured lymphocytes were analyzed with standard, G- and C-banding techniques. The analyses revealed 5 individuals with a variant chromosome #1 (1 qh +) and 1 individual with an extra small unidentifiable fragment or ring chromosome in about 50% of the cells. In the remaining 14 couples, an increased frequency of chromosomal breakage was found, compared to the frequencies in 11 couples with 2 children and no reported abortions. Out of 40 individuals (45%) in the families with fetal wastage 18 have cytogenetic abnormalities. None of the 22 controls showed such abnormalities.