In-vitro and in-vivo susceptibility of Borrelia burgdorferi to azithromycin
- 1 January 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 25 (suppl A) , 33-38
- https://doi.org/10.1093/jac/25.suppl_a.33
Abstract
The in-vitro and in-vivo susceptibility of Borrelia burgdorferito tetracycline, erythromycin and azithromycin was investigated. A macrodilution broth technique was used to determine MBCs. B. burgdorferi was most susceptible to azithromycin (MBC 0.04 mg/l) followed by erythromycin (MBC 0.16 mg/l) and tetracycline (MBC 1.6 mg/l). Syrian hamsters were used to determine ED 50 s for the three antimicrobials. Azithromycin was most effective in the elimination of spirochaetes from experimentally infected hamsters with an ED 50 of 3.71 (±1.9) mg/kg followed by tetracycline (ED 50 15.6 (±4.58) mg/kg). Erythromycin possessed low activity, having an ED 50 of 122.2 (±51.9) mg/kg. Tissue concentrations of azithromycin exceeding the MBC were present 24 h after the final treatment.Keywords
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