Use of the Dr Hemagglutinin of UropathogenicEscherichia colito Differentiate Normal from Abnormal Red Cells in Paroxysmal Nocturnal Hemoglobinuria

Publisher Website
Google Scholar
Abstract
To the Editor: Paroxysmal nocturnal hemoglobinuria (PNH) is a syndrome characterized by red cells with an increased sensitivity to lysis by complement. The total population of red cells in patients with PNH contains normal PNH-I and abnormal PNH-III cells.1 PNH-III cells are devoid of decay-accelerating factor (DAF), a 75,000-dalton membrane protein that is involved in the regulation of the complement cascade.2 The membrane defect of red cells in PNH may lead to chronic hemolytic anemia.We have shown previously that a hemagglutinin of uropathogenic Escherichia coli recognizes the Dr blood-group antigen, a component of the IFC, or Cromer, blood-group complex. . . .