Faculty Opinions recommendation of Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

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Abstract
As one of three genome-wide studies of type 2 diabetes (T2D) published in this issue {1, 2}, this case-control study used Finnish and Swedish subjects who were characterized for disease status and an array of 18 phenotypes (glucose tolerance, insulin secretion, lipids, apolipoproteins, anthropometric measures, etc.) in a genome-wide search for genes controlling risk to T2D, a major public health burden. Subjects were a mix of population-based matched cases and controls, plus discordant sib pairs. Careful analyses confirmed associations between T2D status with intronic markers in IGF2BP2 and CDKAL1, replicated associations between markers near SLC30A8 and HHEX and a marker 125kb from CDKN2A-B on chr 9. Testing for association with the available quantitative phenotypes showed that a SNP in glucose regulatory protein (GCKR) on chr 2 accounted for 1% of the variation in triglyceride levels in these samples.

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