Evidence for a pharmacokinetic interaction between ibuprofen and meptazinol in the mouse
- 1 November 1984
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 36 (11) , 779-781
- https://doi.org/10.1111/j.2042-7158.1984.tb04874.x
Abstract
Of a variety of non-steroidal anti-inflammatory drugs administered concurrently with meptazinol (p.o.), only ibuprofen potentiated the antinociceptive response (mouse, hot-plate test) to the opioid. In addition, the brain tritium concentration of mice given [3H]meptazinol (p.o. or i.v.) was significantly raised by the oral administration of ibuprofen. It is argued that the interaction between these drugs is pharmacokinetic in nature, due probably to an action of ibuprofen on the biotransformation of meptazinol.Keywords
This publication has 2 references indexed in Scilit:
- A review of the biological properties and metabolic disposition of the new analgesic agent, meptazinolGeneral Pharmacology: The Vascular System, 1978
- Studies on the metabolism of meptazinol, a new analgesic drug.Published by Wiley ,1976