Interleukin-10 plays an early role in generating virus-specific T cell anergy
Open Access
- 1 January 2007
- journal article
- Published by Springer Nature in BMC Immunology
- Vol. 8 (1) , 8
- https://doi.org/10.1186/1471-2172-8-8
Abstract
Infection of mice with the Armstrong strain of lymphocytic choriomeningitis virus (LCMVARM) leads to a robust immune response and efficient viral clearance. This is in contrast to infection with the variant strain LCMVClone13, which causes functional inactivation of effector T cells and viral persistence. The mechanism by which LCMVClone13 suppresses the antiviral immune response and persists in its host is unknown.Keywords
This publication has 31 references indexed in Scilit:
- Interleukin-10 determines viral clearance or persistence in vivoNature Medicine, 2006
- Resolution of a chronic viral infection after interleukin-10 receptor blockadeThe Journal of Experimental Medicine, 2006
- Avoiding the kiss of death: how HIV and other chronic viruses surviveCurrent Opinion in Immunology, 2002
- Quantitative and Qualitative Assessment of Human Immunodeficiency Virus Type 1 (HIV‐1)–Specific CD4+T Cell Immunity togagin HIV‐1–Infected Individuals with Differential Disease Progression: Reciprocal Interferon‐γ and Interleukin‐10 ResponsesThe Journal of Infectious Diseases, 2001
- Interleukin-10 and the Interleukin-10 ReceptorAnnual Review of Immunology, 2001
- The dynamics of the cellular immune response to HIV infection: implications for vaccinationPhilosophical Transactions Of The Royal Society B-Biological Sciences, 2000
- Viral Subversion of the Immune SystemAnnual Review of Immunology, 2000
- Viral interleukin 10 (IL-10), the human herpes virus 4 cellular IL-10 homologue, induces local anergy to allogeneic and syngeneic tumors.The Journal of Experimental Medicine, 1995
- Subversion of the immune system by pathogensCell, 1994
- Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cellsNature, 1993