Transplantation of Tissues in Hybrids of Inbred Families of Guinea Pigs and the Individuality Differential

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Abstract
If, instead of transplanting tissues from one member of an inbred family of guinea pigs to another member of the same family, we transplant from a hybrid between two inbred families to another hybrid of the same kind, the results become more unfavorable, in accordance with the greater difference in average genetic constitution between host and donor to be expected under these conditions. In accordance with expectation the average of the results obtained in this series of transplantations, as a whole, is much superior to ordinary homoiotransplantations and corresponds approximately to the results of ordinary (brother to brother) syngenesiotransplantation. The result of transplantations between hybrids of the same inbred families, when donor and host are brothers or sisters, is much superior to ordinary syngenesiotransplantations in non-inbred families, but is somewhat less favorable than transplantations between non-hybrid brothers belonging to the same inbred family; these results are also in accordance with differences in the genetic constitution in such animals. In accordance with expectation, transplantation from hybrids between inbred families to non-related guinea pigs, either non-inbred or representing hybrids between two inbred families other than those used for the first hybridization, gives ordinary homoio-reactions. We may assume that the severity of the reaction against the transplant is determined by the number of strange gene-derivatives which are introduced with the transplant into the host and by the degree of their strangeness.

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