NARCOLEPSY, PARANOID PSYCHOSIS, AND TARDIVE DYSKINESIA

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Abstract
The case history of a 54-yr-old man with comcomitant narcolepsy, paranoid psychosis and tardive dyskinesia was presented. These disorders may all result from alteration in catecholamines, serotonin [5-hydroxytryptamine] and/or acetylcholine in the CNS. The interactions of the various psychopharmacological agents (amphetamine, impramine, chlorpromazine, trifluoperazine, thioridazine, haloperidol, fluphenazine, trihexylephenidyl and benzotropine) usually used to treat the disorders when they occur separately were considered in terms of current neurotransmitter hypotheses. The management of this case created a pharmacological dilemma; the agents used for treatment of each of the disorders separately exacerbate 1 or both of the other 2 syndromes.

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