Repair With Collagen Tubules Linked With Brain-Derived Neurotrophic Factor and Ciliary Neurotrophic Factor in a Rat Sciatic Nerve Injury Model

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Abstract
NERVE INJURY, due to either deliberate surgical resection or inadvertent nerve transection, will often leave significant cosmetic and functional deficits in the patient. However, because of the remarkable plasticity of the nervous system, neuronal cell bodies can be maintained, neurons can regenerate by axonal sprouting, and functional synapses can form, leaving the patient with some recovery of sensation or function.1 Manipulation of any of these regenerative steps can improve clinical outcome and serves as the focus of intense basic and clinical research.