Effect of a New Anti‐Plaque Agent (CK‐0569A) on Developing Plaque and Gingivitis in Man

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Abstract
This study investigated the effect of l,4‐bis[3‐(n‐hexylcarbamylguanidine)propyl]piperazine dimethanesulfonic acid salt (CK‐0569A), used as a mouthrinse, on the development of plaque and gingivitis in humans. Fourteen dental students participated in a double‐blind cross‐over study. At the start of each of the two 14‐day periods of mouthrinsing (one period with CK‐0569A and one period with a placebo solution) the participants were examined for the presence of plaque (PlI) and gingivitis (GI). In addition, supragingival plaque samples were obtained and analyzed by darkfield microscopy. Clinical examination of plaque and gingivitis was repeated 4, 7 and 14 days after the start of the no‐toothbrushing periods. Bacterial samples were obtained after 7 and 14 days of trial.The results demonstrated that a mouthrinse containing CK‐0569A prevented the colonization of motile + curved rods and spirochetes in developing plaque. Furthermore, rinsing twice daily with 0.1% solution CK‐0569A significantly reduced the amount of dental plaque formed and retarded the development of gingivitis.

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