Glutamic Oxalacetic Transaminase in Serum and Cerebrospinal Fluid of Patients with Cerebrovascular Accidents

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Abstract
THE existence of a so-called "blood–brain barrier" is a well known phenomenon. Its presence with respect to glutamic oxalacetic transaminase has been mentioned in a few reports, usually when an elevation of the enzyme in the serum was not reflected in the spinal fluid.1 Recently, more definite evidence of a barrier was shown in dogs with experimental cerebral infarction, in which marked elevation of spinal-fluid transaminase was associated with only minimal change of serum levels.2 Conversely, high serum levels resulting from acute hepatic poisoning were not reflected in the spinal fluid.3 All these studies intimated that an elevation of serum . . .