Hormonal regulation of calcium transport in thick ascending limb renal tubules

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Abstract
Net Ca efflux .**GRAPHIC**. was compared in isolated perfused cortical and medullary segments of the thick ascending limb of Henle of the rabbit kidney. In response to the addition of calcitonin to the bathing medium, cortical segments showed no change in .**GRAPHIC**. in medullary segments .**GRAPHIC**. increased significantly. Similar studies substituting 8-bromo(8-Br)cAMP in concentrations of 10-4 M or lower in the bath showed no effect on .**GRAPHIC**. in either segment. When the concentration of 8-BrcAMP in the bath was increased to 10-3 M, .**GRAPHIC**. rose significantly in both segments. These results indicate heterogeneity of response to calcitonin in the cortical and medullary segments of the thick ascending limb of Henle, but a similar response of Ca transport to cAMP. Because parathyroid hormone stimulates net Ca efflux in the cortical but not in the medullary segments of the thick ascending limb of Henle, cAMP may be the mediator of the actions of both calcitonin and parathyroid hormone.

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