Membrane Recognition and Targeting by Lipid-Binding Domains
- 16 December 2003
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science's STKE
- Vol. 2003 (213) , re16
- https://doi.org/10.1126/stke.2132003re16
Abstract
Modular domains that recognize and target intracellular membranes play a critical role in the assembly, localization, and function of signaling and trafficking complexes in eukaryotic cells. Large domain families, including PH, FYVE, PX, PHD, and C2 domains, combine specific, nonspecific, and multivalent interactions to achieve selective membrane targeting. Despite structural and functional diversity, general features of lipid recognition are evident in the various membrane-targeting mechanisms.Keywords
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