A New Solution‐phase Parallel Synthesis of 2‐Alkylamino‐3‐aryl‐5‐phenylmethylene‐3,5‐dihydro‐4H‐imidazol‐4‐ones
- 1 May 2003
- journal article
- research article
- Published by Wiley in Chinese Journal of Chemistry
- Vol. 21 (5) , 577-580
- https://doi.org/10.1002/cjoc.20030210520
Abstract
Thirteen new 2‐alkylaminoimidazolones (4) were rapidly synthesized by a new solution‐phase parallel synthetic method, which includes aza‐Wittig reaction of iminophosphorane (1) with aromatic iso‐cyanate to give carbodi‐imide (2) and subsequent reaction of 2 with various aliphatic primary amine in a parallel fashion. The products were confirmed by 1H NMR, MS, IR and X‐ray crystallographic analysis. The unusual selectivity of the cyclization was probably due to the geometry of the guanidine intermediate.Keywords
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