The enzymatic and mass spectrometric identification of 2-oxophytanic acid, a product of the peroxisomal oxidation ofL-2-hydroxyphytanic acid

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Abstract
A previously unreported metabolite of the mammalian phytanic acid breakdown pathway, 2-oxophytanic acid, was isolated and analysed by mass spectrometry. The metabolic origin of the 2-oxoacid is the oxidation by a rat kidney peroxisomal H2O2-generating oxidase of L-2-hydroxyphytanic acid, a well-established intermediate in phytanic acid α-oxidation.

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