Metabolism of Papaverine I. Identification of Metabolites in Rat Bile
- 1 January 1975
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 5 (7) , 413-420
- https://doi.org/10.3109/00498257509056111
Abstract
1. After hydrolysis with glusulase of bile from rats treated with papaverine, four metabolites (A, B, C and D) were separated. 2. The structures of A, B and C were established as the monodemethylated compounds, 4′-desmethyl-, 7-desmethyl-, and 6-desmethylpapaverine, respectively. 3. D was formed from papaverine by bis-demethylation. Since it was found in cat bile after administering either A or C, but not B, it was identified as 4′,6-desmethylpapaverine.Keywords
This publication has 4 references indexed in Scilit:
- Metabolism of Papaverine III. Effect of Phenobarbital, 3-Methylcholanthrene and SKF 525-A Pre-treatmentin vivoandin vitroXenobiotica, 1975
- Metabolism of Papaverine II. Species DifferencesXenobiotica, 1975
- The excretion of 3H-papaverine in the ratBiochemical Pharmacology, 1973
- Opium Alkaloids VII. Isolation of a New Benzylisoquinoline Alkaloid. Synthesis and NMR Studies of Papaveroline Trimethyl EthersJournal of Pharmaceutical Sciences, 1968